Regenerative Medicine

The body has innate abilities for healing and regeneration. Regenerative medicine seeks to harness this power and provide treatments that are specifically designed to help the body heal and restore function. At The Center for Manual Medicine, we offer regenerative medicine treatments, including Platelet Rich Plasma (PRP) and Prolotherapy for our patients in Topeka, Manhattan and Holton, KS, and surrounding areas.


Dr. Frye is among the first doctors in the United States to have certification in Musculoskeletal Sonography, and The Center for Manual Medicine is the first practice in Kansas to be certified for musculoskeletal ultrasound by the American Institute of Ultrasound Medicine (AIUM). Rather than the static images of conventional ultrasound, this type of ultrasound provides information about the range of motion of ligaments and tendon, which is useful when evaluating problems related to the muscles and joints.


The safety, accuracy and cost-effectiveness of this technology, compared to MRI images, has resulted in rapid growth. Based on the information obtained through ultrasound, Dr. Frye and the chiropractors at The Center for Manual Medicine develop a plan for regenerative medicine therapy that is tailored to the specific needs of each patient. We utilize a multi-disciplinary approach to facilitate rehabilitation and treat the underlying causes of pain.


Additional information about the regenerative medicine therapies, Platelet Rich Plasma (PRP) and Prolotherapy, manual medicine, and physical therapy services available to our patients in the Topeka, KS, Manhattan, KS, and Holton, KS areas can be found on our website. Please contact The Center by telephone at (785) 271-8100 to schedule an appointment.


Injection Therapy


Musculoskeletal ultrasound

Just as ultrasound is used to look at structures such as gallbladders, veins and fetuses, it also can visualize problems in tendons and ligaments. This is especially useful in the shoulder with the rotator cuff tendons. Tears and other problems of tendons, ligaments and bursa can be seen.

Ultrasound guided injections

Ultrasound imaging is used while injecting to guide the needle towards the desired point of pathology. The most common cause of injection failure is not getting medication where it is needed. For example, shoulder bursa injections without guidance have a low level of accuracy. Studies show that injections are accurate only between 29% and 70 % even for skilled injectors. A recent study in The Journal of Rheumatology [2004 Feb; 31 (2) 308-314] showed a 35 point improvement on a 100 point visual analog pain scale with ultrasound guided injections while those without ultrasound guidance improved only an average of 7 points.

Ultrasound guidance can be used for many injections including those of the knee, hip and shoulder.

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Local Injections

PRP Injections

Dr. Frye has started an exciting new injection procedure. He has been training with Dr. Steven Sampson at the TOBI Institute to bring this exciting procedure to Topeka. To learn more about PRP, Platelet Rich Plasma injections click here.


Also known as proliferative therapy, prolotherapy places a solution of dextrose into a damaged tendon or ligament. The dextrose acts as a proliferant by triggering the bodies’ natural healing system which then begins to repair and strengthen injured ligaments and tendon. This reduces pain and produces and more stable joint. Prolotherapy is used to treat chronic joint pain caused by ligament or tendon damage. Examples include osteoarthritis also known as degenerative arthritis. As the joints wear down ligaments become loose and tendon insertions may be painful. Almost any joint can be treated from shoulder, hips and knees to feet, fingers and toes. Chronic tendonitis such as the elbow, shoulder, knee or foot respond well to prolotherapy. Chronic back and neck pain unresolved with other treatment may respond to prolotherapy.

Prolotherapy is not used for other types of arthritis such as rheumatoid arthritis or other inflammatory arthritis and connective tissue diseases. Generally it is not used for new or acute injuries.

Prolotherapy is considered experimental treatment and is not covered by most insurance companies including Medicare. It is usually reserved for problems that haven’t responded
to traditional methods including medication, physical therapy and cortisone injections.

Prolotherapy involves injections into the tender areas throughout the painful area. There is usually some increased pain for a few days after the treatment. This is treated with ice and Tylenol. Anti-inflammatory medications should not be used after the injection. These include aspirin, Advil (ibuprofen), Aleve (naproxen) or other “NSAID” drugs including prescription medication. Injections are done in a series every 2-4 weeks. Most problems need between 2 and 4 sets of injections. Being in good health and eating good sources of protein with supplemental vitamins that help healing can produce a better result.

The cost for prolotherapy is between $150 and $300 per area treated depending on the area for each set of injections.


Cortisone injections can treat many conditions including tendonitis, bursitis, arthritis, capsulitis, and fasciitis. These are all areas with inflammation and cortisone is a strong anti-inflammatory.


  1. Shoulder: Rotator cuff tendonitis, bursitis and impingement, frozen shoulder and arthritis.
  2. Elbow: Tennis or golfer’s tendonitis, bursitis.
  3. Wrist and Hand: Arthritis, tendonitis, trigger finger or trigger thumb, carpal tunnel syndrome.
  4. Hip: Bursitis and arthritis.
  5. Knee: Arthritis, tendonitis and bursitis
  6. Ankle and foot: Tendonitis, heel spurs/plantar fasciitis.

Trigger point injections

Trigger points are painful “knots” in muscles that most commonly occur in the upper back and may cause a radiating pain syndrome. They are often treated with massage and direct pressure, but when necessary they can be injected with anesthetic agents and a small amount of cortisone to give relief.

Call us at (785) 271-8100
The Center for Manual Medicine
5000 SW 21st ST. Topeka, KS 66604
Copyright 2017 by Center for Manual Medicine