Knee pain can often be mechanical. This is to say that actions at the foot and hips cause excess stress at the knee. Think of your body as a chain, a “mechanical chain.” What happens at one end of the chain, affects the other end of the chain. The knee the middle-link between foot and the hip. The knee can commonly go into a valgus position, i.e. knock-kneed position, due to foot overpronation and/or hip weakness. This places abnormal stress on the knee. Physical therapy, orthotics, and bracing are good front-line treatments to address mechanical deficits. Injection therapy is helpful in moderate to severe cases for ongoing pain. Regenerative therapy can improve ligament laxity.